Biometrical Letters

ISSN:1896-3811

Submit manuscript
Volume (53) Number 2 pp. 69-82

M. Iftakhar Alam 1

1Institute of Statistical Research and Training, University of Dhaka, Dhaka-1000, Bangladesh

A comparison between the continual reassessment method and D-optimum design for dose finding in phase I clinical trials

Abstract

The continual reassessment method is a model-based procedure, described in the literature, used to determine the maximum tolerated dose in phase I clinical trials. The maximum tolerated dose can also be found under the framework of D-optimum design, where information is gathered in such a way so that asymptotic variability in the parameter estimates in minimised. This paper investigates the two methods under some realistic settings to explore any potential differences between them. Simulation studies for six plausible dose-response scenarios show that D-optimum design can work well in comparison with the continual reassessment method in many cases. The D-optimum design is also found to allocate doses from the extremes of the design region to the patients in a trial.

Keywords: Dose finding studies, Phase I trial, Maximum tolerated dose, Continual reassessment method, D-optimum design

DOI: 10.1515/bile-2016-0006

For citation:

MLA Alam, M. Iftakhar. "A comparison between the continual reassessment method and D-optimum design for dose finding in phase I clinical trials." Biometrical Letters 53.2 (2016): 69-82. DOI: 10.1515/bile-2016-0006
APA Alam, M. I. (2016). A comparison between the continual reassessment method and D-optimum design for dose finding in phase I clinical trials. Biometrical Letters 53(2), 69-82 DOI: 10.1515/bile-2016-0006
ISO 690 ALAM, M. Iftakhar. A comparison between the continual reassessment method and D-optimum design for dose finding in phase I clinical trials. Biometrical Letters, 2016, 53.2: 69-82. DOI: 10.1515/bile-2016-0006